Jérôme Golebiowski


chercheur (Professor)
Institut de Chimie de Nice (ICN)
Centre national de la recherche scientifique (CNRS)



Molecular Modeling, psychophysiology: from receptor to behavior: My research projects are focused on ligand-receptor systems. They are centered on the  description of the molecular basis of chemical senses and more particularly the sense of smell. The long-term project is to redefine structure-odor relationships with the take into account of odorant receptors expressed in our neurons. In parallel, we are interested in the link between the structure of an odorant and the emotion.

  • Ongoing research projects:
    • The OBP-Optinose project is funded by ANR (2019-2022): Odorant Binding Proteins-based biomimetic optical nose
    • The ChemoSuz project is funded by ANR (2019-2021):  Chemogenetic characterization of the egg-laying behavior of the fruit pest species Drosophila suzukii
    • The DoctOR project is funded by CNRS (PRC Korea 2018-2019): Targeting Odorant receptors for healing your body and your mind
    • The CrackOlf Project is funded by Univ. Côte d’Azur (2018-2019): Cracking Olfactory receptor activation by computational tools
    • The PrediScent Project is funded by Univ. Côte d’Azur (2018-2019): Numerical models for predicting smell and emotion from chemical features
    • The Demeter project is funded by ANR (2017-2021):  Less pesticides and more food!
    • The Emoton project is funded by the Interdisciplinary Section of CNRS (2016-2018) : Olfaction as a tool to promote motivation and autonomy 
    • The NeurOlf project is funded by the call jointly launched by ANR and NSF(2015-2018) in Computational Research in Neuroscience: Predicting odorant-dependent and independent olfactory neuron activation based on receptor dynamics

Selected publications:

Recent publications: 2012-

Licon CC, Bosc G, Sabri M, Mantel M, Fournel A, Bushdid C, Golebiowski J, Robardet C, Plantevit M, Kaytoue M2, Bensafi M*
Chemical features mining provides new descriptive structure-odor relationships

J.B. Chéron, A. Soohoo, J. Golebiowski, S. Antonczak, P. Jiang*, S. Fiorucci*
Conserved residues control the allosteric signaling pathway of the mammalian sweet taste receptor
C. Bushdid, C.A. de March, J. Topin, M. Do, H. Matsunami*, J. Golebiowski* 
Mammalian class I odorant receptors exhibit a conserved vestibular binding pocket

X. Cong*, J. Golebiowski*
Allosteric Na+-binding site modulates CXCR4 activation
Physical Chemistry Chemical Physics, 2018, 20, 24915-24920, 10.1039/C8CP04134B

X. Cong*, S. Fiorucci, J. Golebiowski* 
Activation dynamics of the Neurotensin Receptor 1
Journal of Chemical Theory and Computation, 2018, 14(8), 4467-4473

C. Bushdid, C.A. de March, S. Fiorucci, H. Matsunami*, J. Golebiowski*
Agonists of G Protein-Coupled Odorant Receptors are Predicted from Chemical Features
The Journal of Physical Chemistry Letters, 2018, 9, 2235-2240

C.A. de March, J. Topin, E. Bruguera, G. Novikov, K. Ikegami, H. Matsunami*, J. Golebiowski*
Odorant receptor 7D4 activation dynamics
Angewandte Chemie International Edition, 2018, 57, 4554-4558

C. Bushdid, C.A. de March, H. Matsunami, J. Golebiowski*
Molecular modeling of Odorant Receptors.
Methods in Molecular Biology, 2018, 1820:77-93
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