Meeting de rentrée de l'Académie d'Excellence 4 - Complexité et Diversité du Vivant -18 Septembre 2018


L’Académie 4 vous invite à la présentation des nouveaux projets de stages de Master en binômes interdisciplinaires 2018 qui se tiendra le mardi 18 Septembre 2018 de 9h à 13h, en salle de conférence de l’IPMC à Sophia Antipolis (660 route des lucioles, 06560 Valbonne).

Les porteurs de 5 projets de stages de Master en binômes interdisciplinaires sélectionnés en Juin 2018 présenteront leurs offres de stage.

Les responsables de l’Académie 4 seront également présents pour répondre à vos questions concernant la gestion administrative et financière de votre projet IDEX.

Nous aurons le plaisir d'accueillir deux Professeurs Emeritus invités, Heinz Arnheiter (C3M) et William Catterall (IPMC).

Pour clôturer cette matinée, nous recevrons le Professeur Pierre Antoine Gourraud, Bio-informaticien, PUPH à l'Ecole de Médecine de l'Université de Nantes en France et Professeur Assistant au département de Neurologie de l'Université de San Francisco aux USA.



9h00 - Introduction des présentations de stages par Bruno Antonny (Chairman : Pierre Abad)

9h05 - F Duprat - T PapadopouloEPI-ANALYSE - Développement d'outils de détection efficace des crises d'épilepsie chez la souris par analyse d'image et de signal EEG.

9h25 - AS Rousseau - R ZoryVIF-APAS - Vieillissement, Immuno-métabolisme et Fragilité : effets d'un Programme d’Activités Physiques Adaptées à des fins de Santé.

9h45 - C Rovère - E DebreuveNutriMorph - Lipides nutritionnels et remodelage cérébral: mesure de la plasticité gliale grâce à un outil de morphométrie cellulaire.

10h05 - M Duca - T Virolle - GIfTED - Petites molécules synthétiques induisant la différenciation des cellules initiant le Gliobastome: nouvelles perspectives en chimiothérapies anticancéreuses.

10h25 - JP Comet - F Delaunay - ModHyMet - Modélisation hybride du métabolisme cellulaire.


10h45 - Pause Café


10h55 - Introduction des présentations de professeurs invités par Pascal Barbry (Chairman : Pierre Abad)

11h00 - Pr H Arnheiter, MD, NIH Bethesda USA, en visite au C3M Nice, "Syndromic deafness and the role of the transcription factor MITF"

11h30 - Pr W Catterall,  PhD, University of Washington Seattle USA, en visite à l'IPMC Sophia, ”Electrical Signaling at Atomic Resolution”

12h00 Keynote séminaire interdisciplinaire - Pr PA Gourraud, PUPH, Nantes, "The Multiple Sclerosis Bioscreen: Beyond genetics, a precision medicine platform integrating genomic, clinical and imaging data for complex diseases".


13h - Buffet et discussions 

Abstract du Pr H Arnheiter, MD, Scientific emeritus NIH Bethesda USA, en visite au C3M Nice

"Syndromic deafness and the role of the transcription factor MITF".

The microphthalmia-associated transcription factor MITF has emerged a jack-of-all-trades able to coordinate many aspects of developmental and cell biology by controlling the expression of a great variety of target genes. Its key function is in regulating neural crest-derived melanocytes and their malignant derivatives. In mammals, melanocytes play a particularly interesting role in hearing. During embryonic development, a subset of their precursors lodge in the inner ear where they integrate as intermediate cells in the so-called stria vascularis. When MITF is rendered non-functional by mutations, strial melanocytes are missing, which in turn leads to a change in the ionic composition of the endolymph and an inability of auditory hair cells to release neurotransmitters and stimulate the auditory nerve. In humans, the resulting disorder is called Waardenburg Syndrome (WS) IIa, which is usually characterized by a combination of congenital deafness with pigmentation defects in skin, hair, and iris. It is normally inherited in an autosomal dominant fashion but may show considerable phenotypic variations within families. I will discuss some of the WS IIa mutations and demonstrate how an inconspicuous intronic nucleotide transversion in mice can lead to the complete absence of MITF function.

Abstract du Pr William A. Catterall, Department of Pharmacology, University of Washington Seattle USA, en visite à l'IPMC Sophia Antipolis

”Electrical Signaling at Atomic Resolution”.

Electrical signals initiated by voltage-gated sodium and calcium channels initiate rapid physiological events from bacteria to man. Through structural studies of a bacterial ancestor of eukaryotic sodium and calcium channels, we have elucidated the structural basis for voltage-dependent activation and inactivation of these ion channels, their mechanism of ion conductance and selectivity, and the sites and mechanisms of action of channel-blocking drugs that are widely used in therapy of human diseases.

Abstract - Keynote séminaire interdisciplinaire - Pr PA Gourraud, PhD MPH, ITUN - CRTI - UMR Inserm 1064 University of Nantes – Nantes University Hospitals, France

"The Multiple Sclerosis Bioscreen: Beyond genetics, a precision medicine platform integrating genomic, clinical and imaging data for complex diseases".

Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system. MS affects approximately 2.3 million people worldwide and constitutes an example of a multi-factorial, complex condition. An increasingly difficult challenge for clinicians, researchers and patients is to collate and interpret diverse types of clinical and biologic data to track disease progression, forecast outcomes, and inform therapeutic decision-making. We present a precision medicine application developed for multiple sclerosis (MS): the MS BioScreen. This new tool addresses the challenges of dynamic management of a complex chronic disease; the interaction of clinicians and patients with such a tool illustrates the extent to which translational digital medicine – i.e. the application of information technology to medicine—has the potential to radically transform medical practice.
METHODS: The scalability of the data stored on the platform, its very dynamic evolution and diverse nature (clinical and therapeutic data; brain, spinal cord and eye imaging; genetics; biomarkers), as well as the continuous development of our algorithmic core requires a flexible architecture. On the back-end, our infrastructure is cloud-based and includes: a SQL database combined with a custom PACS (MRI imaging) installation; AWS Elastic Computing resources; and HTTP RESTful communications between the different services.
RESULTS: The MSBioscreen front-end is currently an iPad app that gives clinicians access to tailored visualizations of an individual patient’s disease trajectory within an algorithmically-generated reference group, assessing the degree of progression severity in the context of similar patients. We introduce three key evolutionary phases in displaying data to health care providers, patients, and researchers: visualization (accessing data), contextualization (understanding the data), and actionable interpretation (real-time use of the data to assist decision-making).
PERSPECTIVE: This project proposes a tractable road map to address the challenge of integrating health big data into an actionable tool for personalized medicine. Together these form the stepping-stones that are expected to accelerate standardization of data across platforms, promote evidence-based medicine, support shared decision-making, and ultimately lead to improved outcomes.

Short Bio
Pierre-Antoine Gourraud is Professeur des Universités Praticien-Hospitalier of the School of Medicine of the Nantes University in France and associate professor at the Department of Neurology of the University of California at San Francisco (UCSF), USA. He is a former student of the Ecole Normale Supérieure de Lyon, France in the department of molecular and cellular Immunobiology.
Prof. Gourraud has developed bioinformatics tools for the study of immunogenetic markers at the NCBI, he performed numerous genetic association studies on various diseases (rheumatoid arthritis, multiple sclerosis, and leukaemia), and he conducted population genetics analyses of European populations (HLA and KIR genes). He developed software dedicated to statistical genetics and designed an algorithm to support decision making for the treatment of haematological diseases and management of Bone Marrow Donor Registries in France and in the US.



660 Route des Lucioles VALBONNE, 06560


IPMC, Salle de conférence


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