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Exposome, genetics and disease: Southern Brazil as a model

Seminar run by Enzo Lalli (IPMC)

13/06/2019   :   10h00
Salle des Séminaires MSI, 1361 Route des Lucioles, 06560 Valbonne, France
 Speaker: Enzo Lalli (IPMC)
Publication : 13/06/2019
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Speaker: Enzo Lalli (IPMC)

Abstract: The exposome is defined as the sum of all environmental influences and the accumulation of a person's environmental exposures from conception onward, including all factors that are non-genetic. It represents a biological index of our nurture and the context in which specific exposures have impact on health. Our program aims to investigate how the interaction between genetic and environmental factors modulates prevalence of cancer and other diseases. These studies will leverage on the unique situation present in the State of Paraná in Southern Brazil, where the prevalence of a specific, low-penetrance germline mutation of the TP53 tumour suppressor gene is high in the population. We have developed Geographical Information Systems (GIS) to build maps of the state of Paraná for the visualization and comparison of statistical data on environment (distribution of environmental pollutants, water contaminants etc.) and health (congenital malformations, all major types of cancer, neurodegenerative diseases etc.; However, the importance of our project far exceeds its application to a, though large, population in Latin America, since it will shed new light on the factors involved in determining cancer development in carriers of other low-penetrance TP53 alleles which are present throughout the world. Our project relies on the long-lasting and fruitful partnership already established among the project participants since more than 15 years.